BDBM50273817 7-Pyridin-3-yl-2H-1,4-benzothiazin-3(4H)-one::CHEMBL509971

SMILES O=C1CSc2cc(ccc2N1)-c1cccnc1

InChI Key InChIKey=QVFBOIKMDDLOQP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50273817   

TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50273817(7-Pyridin-3-yl-2H-1,4-benzothiazin-3(4H)-one | CHE...)
Affinity DataIC50:  12nMAssay Description:Inhibition of CYP11B2 in human V79MZ cells using [3H]-11-deoxycorticosterone as substrate incubated for 1 hr prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50273817(7-Pyridin-3-yl-2H-1,4-benzothiazin-3(4H)-one | CHE...)
Affinity DataIC50:  525nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50273817(7-Pyridin-3-yl-2H-1,4-benzothiazin-3(4H)-one | CHE...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50273817(7-Pyridin-3-yl-2H-1,4-benzothiazin-3(4H)-one | CHE...)
Affinity DataIC50:  525nMAssay Description:Inhibition of CYP11B1 in human V79MZ cells using [3H]-11-deoxycorticosterone as substrate incubated for 1 hr prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed