BDBM50274001 CHEMBL462301::N-[5-(Benzoyl-ethyl-amino)-1-(2-carbamoyl-ethyl)-1H-benzoimidazol-2-yl]-4-cyano-benzamide

SMILES CCN(C(=O)c1ccccc1)c1ccc2n(CCC(N)=O)c(NC(=O)c3ccc(cc3)C#N)nc2c1

InChI Key InChIKey=VRASPPLZZRUGFU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50274001   

TargetTyrosine-protein kinase ITK/TSK(Human)
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274001(N-[5-(Benzoyl-ethyl-amino)-1-(2-carbamoyl-ethyl)-1...)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant ITK by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274001(N-[5-(Benzoyl-ethyl-amino)-1-(2-carbamoyl-ethyl)-1...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human ITK expressed in chicken DT40 cells assessed as B cell receptor-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274001(N-[5-(Benzoyl-ethyl-amino)-1-(2-carbamoyl-ethyl)-1...)
Affinity DataIC50: 310nMAssay Description:Inhibition of TXKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274001(N-[5-(Benzoyl-ethyl-amino)-1-(2-carbamoyl-ethyl)-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274001(N-[5-(Benzoyl-ethyl-amino)-1-(2-carbamoyl-ethyl)-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274001(N-[5-(Benzoyl-ethyl-amino)-1-(2-carbamoyl-ethyl)-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Tec kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed