BDBM50274228 1-{3-[6-(1-Hydroxy-1-methyl-ethyl)-1-oxy-pyridin-3-yl]-phenyl}-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid cyclopropylamide::CHEMBL485620

SMILES CC(C)(O)c1ccc(c[n+]1[O-])-c1cccc(c1)-n1cc(C(=O)NC2CC2)c(=O)c2cccnc12

InChI Key InChIKey=GVABMKVKGRIEOY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50274228   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274228(1-{3-[6-(1-Hydroxy-1-methyl-ethyl)-1-oxy-pyridin-3...)
Affinity DataIC50: 6.20nMAssay Description:Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274228(1-{3-[6-(1-Hydroxy-1-methyl-ethyl)-1-oxy-pyridin-3...)
Affinity DataIC50: 5.01E+4nMAssay Description:Displacement of [35S]MK-499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274228(1-{3-[6-(1-Hydroxy-1-methyl-ethyl)-1-oxy-pyridin-3...)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed