BDBM50274414 (+)-3-{(Cyclopropylmethyl)[3-(5-fluoro-1H-indol-3-yl)-1-methylpropyl]amino}-8-fluorochromane-5-carboxamide::(-)-3-{(Cyclopropylmethyl)[3-(5-fluoro-1H-indol-3-yl)-1-methylpropyl]amino}-8-fluorochromane-5-carboxamide::CHEMBL483370

SMILES CC(CCc1c[nH]c2ccc(F)cc12)N(CC1CC1)C1COc2c(F)ccc(C(N)=O)c2C1

InChI Key InChIKey=RTLBWSTYHWYGOI-UHFFFAOYSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50274414   

Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274414((+)-3-{(Cyclopropylmethyl)[3-(5-fluoro-1H-indol-3-...)
Affinity DataKi:  1.88nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274414((+)-3-{(Cyclopropylmethyl)[3-(5-fluoro-1H-indol-3-...)
Affinity DataKi:  1.88nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274414((+)-3-{(Cyclopropylmethyl)[3-(5-fluoro-1H-indol-3-...)
Affinity DataKi:  10.2nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter in Sprague-Dawley rat frontal cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274414((+)-3-{(Cyclopropylmethyl)[3-(5-fluoro-1H-indol-3-...)
Affinity DataKi:  10.2nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter in Sprague-Dawley rat frontal cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274414((+)-3-{(Cyclopropylmethyl)[3-(5-fluoro-1H-indol-3-...)
Affinity DataIC50:  193nMAssay Description:Inhibition of 5-HT transporter-mediated [3H]5HT uptake in human Jar cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274414((+)-3-{(Cyclopropylmethyl)[3-(5-fluoro-1H-indol-3-...)
Affinity DataIC50:  333nMAssay Description:Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274414((+)-3-{(Cyclopropylmethyl)[3-(5-fluoro-1H-indol-3-...)
Affinity DataIC50:  193nMAssay Description:Inhibition of 5-HT transporter-mediated [3H]5HT uptake in human Jar cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed