BDBM50274654 2-Methyl-3-[4-([3-(1-pyrrolidinyl)cyclopentyl]oxy)phenyl]-4(3H)-quinazolinone::CHEMBL484740

SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCC(C2)N2CCCC2)cc1

InChI Key InChIKey=RWNXKETUEWVUIP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50274654   

TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50274654(2-Methyl-3-[4-([3-(1-pyrrolidinyl)cyclopentyl]oxy)...)
Affinity DataIC50: 3.40nMAssay Description:Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50274654(2-Methyl-3-[4-([3-(1-pyrrolidinyl)cyclopentyl]oxy)...)
Affinity DataIC50: 3.40nMAssay Description:Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50274654(2-Methyl-3-[4-([3-(1-pyrrolidinyl)cyclopentyl]oxy)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human ERG in HEK293 cells assessed as inhibition of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihyd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50274654(2-Methyl-3-[4-([3-(1-pyrrolidinyl)cyclopentyl]oxy)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human ERG in HEK293 cells assessed as inhibition of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihyd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed