BDBM50274667 CHEMBL490269::N-[1-(2-carbamoylethyl)-2-[(4-cyanobenzene)amido]-1H-1,3-benzodiazol-5-yl]-N-methyl-4-(trifluoromethoxy)benzamide

SMILES CN(C(=O)c1ccc(OC(F)(F)F)cc1)c1ccc2n(CCC(N)=O)c(NC(=O)c3ccc(cc3)C#N)nc2c1

InChI Key InChIKey=JMGKVLRBHUHFFV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50274667   

TargetTyrosine-protein kinase ITK/TSK(Human)
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274667(N-[1-(2-carbamoylethyl)-2-[(4-cyanobenzene)amido]-...)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant ITK by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274667(N-[1-(2-carbamoylethyl)-2-[(4-cyanobenzene)amido]-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human ITK expressed in chicken DT40 cells assessed as B cell receptor-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed