BDBM50275603 2,2,2-trifluoro-1-(5-(4-(3-methoxyphenyl)piperazine-1-carbonyl)thiophen-2-yl)ethanone::CHEMBL487370

SMILES COc1cccc(c1)N1CCN(CC1)C(=O)c1ccc(s1)C(=O)C(F)(F)F

InChI Key InChIKey=XTLNRTXUFUFOCB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50275603   

TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275603(2,2,2-trifluoro-1-(5-(4-(3-methoxyphenyl)piperazin...)
Affinity DataIC50: 170nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275603(2,2,2-trifluoro-1-(5-(4-(3-methoxyphenyl)piperazin...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275603(2,2,2-trifluoro-1-(5-(4-(3-methoxyphenyl)piperazin...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytes in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275603(2,2,2-trifluoro-1-(5-(4-(3-methoxyphenyl)piperazin...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed