BDBM50275639 1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-carbonyl)thiophen-2-yl)-2,2,2-trifluoroethanone::CHEMBL521355

SMILES COc1ccc(Cl)cc1N1CCN(CC1)C(=O)c1ccc(s1)C(=O)C(F)(F)F

InChI Key InChIKey=FIMWAKPEWMTONO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50275639   

TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50: 175nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed