BDBM50275831 2-[(1R,2R)-2-(Aminomethyl)-1-(2-thienyl)cyclopropanecarbonyl] isoindoline::CHEMBL471211

SMILES NC[C@@H]1C[C@@]1(C(=O)N1Cc2ccccc2C1)c1cccs1

InChI Key InChIKey=ASCGGWXVCATSKL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50275831   

TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275831(2-[(1R,2R)-2-(Aminomethyl)-1-(2-thienyl)cyclopropa...)
Affinity DataIC50: 13nMAssay Description:Displacement of [alpha,beta-3H(N)]-5-hydroxytryptamine from human cloned SERT expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275831(2-[(1R,2R)-2-(Aminomethyl)-1-(2-thienyl)cyclopropa...)
Affinity DataIC50: 15nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from rat synaptosomal NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275831(2-[(1R,2R)-2-(Aminomethyl)-1-(2-thienyl)cyclopropa...)
Affinity DataIC50: 21nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from human cloned NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275831(2-[(1R,2R)-2-(Aminomethyl)-1-(2-thienyl)cyclopropa...)
Affinity DataIC50: 25nMAssay Description:Displacement of [alpha,beta-3H(N)]-5-hydroxytryptamine from rat synaptosomal SERT expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275831(2-[(1R,2R)-2-(Aminomethyl)-1-(2-thienyl)cyclopropa...)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of 3,4-[ring-2,5,6-3H]dihydroxyphenylethylamine from rat synaptosomal DAT expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50275831(2-[(1R,2R)-2-(Aminomethyl)-1-(2-thienyl)cyclopropa...)
Affinity DataIC50: 5.54E+3nMAssay Description:Displacement of 3,4-[ring-2,5,6-3H]dihydroxyphenylethylamine from human cloned DAT expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed