BDBM50276260 (R)-N-benzyl-N-(1-(1-(2,6-dimethylbenzoyl)piperidin-4-yl)pyrrolidin-3-yl)cyclopropanecarboxamide::CHEMBL471623

SMILES Cc1cccc(C)c1C(=O)N1CCC(CC1)N1CC[C@H](C1)N(Cc1ccccc1)C(=O)C1CC1

InChI Key InChIKey=JMJZSLIIHVSDBK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50276260   

TargetC-C chemokine receptor type 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276260((R)-N-benzyl-N-(1-(1-(2,6-dimethylbenzoyl)piperidi...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276260((R)-N-benzyl-N-(1-(1-(2,6-dimethylbenzoyl)piperidi...)
Affinity DataIC50: 8nMAssay Description:Displacement of [125]Mip1beta form CCR5 receptor expressed in MIP34.10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50276260((R)-N-benzyl-N-(1-(1-(2,6-dimethylbenzoyl)piperidi...)
Affinity DataIC50: 9.80E+3nMAssay Description:Displacement of [3H]dofetilide form human ERG expressed in HEK239 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed