BDBM50276545 CHEMBL450138::N-{[2S,3(R,S)]-2-[4-(1-Benzylpiperidin-4-yl)]ethyl-carbamoyl-3-hydroxy-1-phenylbut-2-yl}-5-[methyl-(methylsulfonyl)amino]-N'-[(R)-1-phenylethyl]isophthalamide

SMILES C[C@@H](NC(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)C(O)C(=O)NCCC1CCN(Cc2ccccc2)CC1)N(C)S(C)(=O)=O)c1ccccc1

InChI Key InChIKey=NKECKRQJWGQLKX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50276545   

TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50276545(N-{[2S,3(R,S)]-2-[4-(1-Benzylpiperidin-4-yl)]ethyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50276545(N-{[2S,3(R,S)]-2-[4-(1-Benzylpiperidin-4-yl)]ethyl...)
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibition of AChE in rat cortex preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed