BDBM50276551 CHEMBL448678::N-{[2S,3(R,S)]-2-[4-(1-Benzylpiperidin-4-yl)]ethylcarbamoyl-3-hydroxy-1-phenylbut-2-yl}-N',N'-dipropyl-5-nitroisophthalamide

SMILES CCCN(CCC)C(=O)c1cc(cc(c1)[N+]([O-])=O)C(=O)N[C@@H](Cc1ccccc1)C(O)C(=O)NCCC1CCN(Cc2ccccc2)CC1

InChI Key InChIKey=ZOVXBMODXBZWHZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50276551   

TargetBeta-secretase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50276551(N-{[2S,3(R,S)]-2-[4-(1-Benzylpiperidin-4-yl)]ethyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human betaAPP695 mutant assessed as inhibition of amyloid beta (1 to 40) production after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50276551(N-{[2S,3(R,S)]-2-[4-(1-Benzylpiperidin-4-yl)]ethyl...)
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of AChE in rat cortex preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed