BDBM50277293 6-methyl-N-((2S)-2-(1-phenylethylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide::CHEMBL474301

SMILES CC(N[C@H]1Cc2ccc(NC(=O)c3cccc(C)c3-c3ccc(cc3)C(F)(F)F)cc2C1)c1ccccc1

InChI Key InChIKey=JWYGHODMDMKPPK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50277293   

TargetSmoothened homolog(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277293(6-methyl-N-((2S)-2-(1-phenylethylamino)-2,3-dihydr...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277293(6-methyl-N-((2S)-2-(1-phenylethylamino)-2,3-dihydr...)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetMicrosomal triglyceride transfer protein large subunit(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277293(6-methyl-N-((2S)-2-(1-phenylethylamino)-2,3-dihydr...)
Affinity DataIC50: 180nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed