BDBM50277361 4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy)phenyl)isothiazole-3-carboxamide::CHEMBL475509

SMILES FC(F)(F)Oc1cccc(NC(=O)c2nscc2NCc2ccncc2)c1

InChI Key InChIKey=HPQJCFJZSWQYAT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50277361   

LigandPNGBDBM50277361(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy...)
Affinity DataIC50: 33nMAssay Description:Inhibition of VEGFR2 assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277361(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy...)
Affinity DataIC50: 41nMAssay Description:Inhibition of VEGFR2 expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277361(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy...)
Affinity DataIC50: 260nMAssay Description:Inhibition of VEGFR1 assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed