BDBM50277407 CHEMBL473288::N-(4-bromophenyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide

SMILES Brc1ccc(NC(=O)c2nscc2NCc2ccncc2)cc1

InChI Key InChIKey=KFOLYIMICUBNES-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50277407   

LigandPNGBDBM50277407(N-(4-bromophenyl)-4-(pyridin-4-ylmethylamino)isoth...)
Affinity DataKi:  70nMAssay Description:Inhibition of VEGFR2 at IC90 concentration by ATP based competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277407(N-(4-bromophenyl)-4-(pyridin-4-ylmethylamino)isoth...)
Affinity DataKi:  90nMAssay Description:Inhibition of VEGFR2 at IC50 concentration by ATP based competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277407(N-(4-bromophenyl)-4-(pyridin-4-ylmethylamino)isoth...)
Affinity DataIC50: 230nMAssay Description:Inhibition of VEGFR2 assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277407(N-(4-bromophenyl)-4-(pyridin-4-ylmethylamino)isoth...)
Affinity DataIC50: 260nMAssay Description:Inhibition of VEGFR1 assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277407(N-(4-bromophenyl)-4-(pyridin-4-ylmethylamino)isoth...)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of VEGFR2 expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed