BDBM50277578 2-(3-(7-hydroxy-1-methyl-4,5-dihydro-1H-benzo[g]indazol-3-yl)propanamido)benzoic acid::CHEMBL483160

SMILES Cn1nc(CCC(=O)Nc2ccccc2C(O)=O)c2CCc3cc(O)ccc3-c12

InChI Key InChIKey=NZGZNXDKXJRISB-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50277578   

TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277578(2-(3-(7-hydroxy-1-methyl-4,5-dihydro-1H-benzo[g]in...)
Affinity DataIC50: 130nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277578(2-(3-(7-hydroxy-1-methyl-4,5-dihydro-1H-benzo[g]in...)
Affinity DataEC50:  840nMAssay Description:Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277578(2-(3-(7-hydroxy-1-methyl-4,5-dihydro-1H-benzo[g]in...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed