BDBM50277674 2-(3-(6-hydroxy-4H-indeno[2,1-d]isoxazol-3-yl)propanamido)benzoic acid::CHEMBL482980

SMILES OC(=O)c1ccccc1NC(=O)CCc1noc-2c1Cc1cc(O)ccc-21

InChI Key InChIKey=FJMNOEYZTHLZFG-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50277674   

TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277674(2-(3-(6-hydroxy-4H-indeno[2,1-d]isoxazol-3-yl)prop...)
Affinity DataIC50: 380nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277674(2-(3-(6-hydroxy-4H-indeno[2,1-d]isoxazol-3-yl)prop...)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277674(2-(3-(6-hydroxy-4H-indeno[2,1-d]isoxazol-3-yl)prop...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277674(2-(3-(6-hydroxy-4H-indeno[2,1-d]isoxazol-3-yl)prop...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using montelukast substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed