BDBM50278798 CHEMBL4172635

SMILES COc1nc(F)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl

InChI Key InChIKey=NWSUDJQTTGDPIR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50278798   

TargetC-C chemokine receptor type 4(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at mouse CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Dog)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at dog CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 158nMAssay Description:Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 316nMAssay Description:Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed