BDBM50279045 (Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-phenylamino}-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylicAcid Methyl Ester::CHEMBL525203

SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C(=O)N(C)C)cc3)c3ccccc3)C(=O)Nc2c1

InChI Key InChIKey=BQUCMYBIGNGMFC-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50279045   

TargetVascular endothelial growth factor receptor 3(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279045((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279045((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279045((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279045((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Affinity DataIC50: 61nMAssay Description:Inhibition of human VEGFR2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279045((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Affinity DataIC50: 82nMAssay Description:Inhibition of human VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279045((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Plk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279045((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279045((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human InsRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279045((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279045((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279045((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279045((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed