BDBM50279257 2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-methoxy-1H-indol-3-yl)propanoic acid::CHEMBL497908::rac-2-(4-But-2-ynyloxy-benzenesulfonyl-amino)-3-(5-methoxy-1H-indol-3-yl)-propionic acid

SMILES COc1ccc2[nH]cc(CC(NS(=O)(=O)c3ccc(OCC#CC)cc3)C(O)=O)c2c1

InChI Key InChIKey=QBMRYLHKTSDMJW-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50279257   

Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279257(2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-methox...)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of MMP2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50279257(2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-methox...)
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50279257(2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-methox...)
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279257(2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-methox...)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of MMP13 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279257(2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-methox...)
Affinity DataIC50: 2.07E+4nMAssay Description:Inhibition of MMP14 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279257(2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-methox...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MMP1 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50279257(2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-methox...)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of TACE in mouse Raw264.7 cells assessed as inhibition of LPS-induced TNFalpha production treated 1 hr before LPS challenge measured 4 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed