BDBM50279692 CHEMBL4159041::US10889592, Compound I-4::US11325917, Compound I-4

SMILES Cc1cnc2c(N)c(sc2n1)C(=O)NCCc1cc(F)c(cc1F)N1CCNCC1

InChI Key InChIKey=QIZBWAFXECHGEM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50279692   

TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
Valo Early Discovery

US Patent
LigandPNGBDBM50279692(CHEMBL4159041 | US10889592, Compound I-4 | US11325...)
Affinity DataIC50: 1.10E+3nMAssay Description:USP28: Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Cor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
Valo Early Discovery

US Patent
LigandPNGBDBM50279692(CHEMBL4159041 | US10889592, Compound I-4 | US11325...)
Affinity DataIC50: 1.10E+3nMAssay Description:Ubiquitin-Rhodamine 110 Assay for USP28 Activity: Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 25(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50279692(CHEMBL4159041 | US10889592, Compound I-4 | US11325...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant human His6-tagged USP25 expressed in baculovirus infected Sf21 insect cells using Ub-Rh110 as substrate pretreated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2020
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 25(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50279692(CHEMBL4159041 | US10889592, Compound I-4 | US11325...)
Affinity DataIC50: 6.00E+3nMAssay Description:USP25: The assay was performed in a final volume of 9 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 25(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50279692(CHEMBL4159041 | US10889592, Compound I-4 | US11325...)
Affinity DataIC50: 6.00E+3nMAssay Description:Ubiquitin-Rhodamine 110 Assay for USP25 Activity: The assay was performed in a final volume of 9 μL in assay buffer containing 20 mM Tris-HCl (p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
US Patent