BDBM50281173 CHEMBL4169359

SMILES Cn1n2ccccc2c(C(=O)Nc2c(F)c(F)c(c(F)c2F)-c2ccccc2)c1=O

InChI Key InChIKey=MUTGDOHUSOREOS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50281173   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery And Clinic

US Patent
LigandPNGBDBM50281173(CHEMBL4169359 | US12162877, Compound 7)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity was assessed by monitoring the reduction of 2,6-dichloroindophenol (DCIP), which is associated with the oxidation of dihydroorota...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery And Clinic

US Patent
LigandPNGBDBM50281173(CHEMBL4169359 | US12162877, Compound 7)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human DHODH (31 to 395 residues) expressed in Escherichia coli BL21(DE3) assessed as inhibition of DC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed