BDBM50287310 CHEMBL4173715

SMILES OC(=O)C[C@]1(CC(F)(F)F)CCc2cc(ccc2C1=O)-c1cnc(NC(=O)Nc2ccc(F)c(F)c2)cn1

InChI Key InChIKey=OTKTZEZTFCAULO-DEOSSOPVSA-N

Data  13 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50287310   

TargetCytochrome P450 2C19(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin) using S-mephenytoin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin) using phenacetin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ACAT2 (unknown origin) by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin) by QPatch assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataEC50: >5.00E+4nMAssay Description:Activation at PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human DGAT2 expressed in baculovirus infected Sf9 insect microsomal membranes using C10-DAG and [3H]-labelled decanoyl-CoA ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human DGAT1 expressed in baculovirus infected Sf9 insect microsomal membranes using C10-DAG and [3H]-labelled decanoyl-CoA ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by QPatch assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin) by QPatch assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) using diclofenac as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) using DEX as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataIC50:  77nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells using [14C] oleic acid as substrate measured after 20 mins by phosphorimaging methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50287310(CHEMBL4173715)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ACAT1 (unknown origin) by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed