BDBM50287927 1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-yl]-3-(4-nitrophenyl)-(E)-2-propenamide::CHEMBL417535

SMILES Oc1ccc2C[C@H]3N(CC4CC4)CCC45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)NC(=O)\C=C\c1ccc(cc1)[N+]([O-])=O

InChI Key

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50287927   

TargetMu-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50287927(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Affinity DataKi:  0.200nMAssay Description:Compound was evaluated for binding affinity against [3H]- DAMGO labeled mu opioid receptor in guinea-pig brain homogenate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetKappa-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50287927(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Affinity DataKi:  0.800nMAssay Description:Compound was evaluated for binding affinity against [3H]- U-69593 labeled kappa1 opioid receptor in guinea-pig brain homogenate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetDelta-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287927(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Affinity DataKi:  5.10nMAssay Description:Compound was evaluated for binding affinity against [3H]- Cl-DPDPE labeled Opioid receptor delta 1 in guinea-pig brain homogenate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetKappa-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50287927(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Affinity DataIC50: 13nMAssay Description:Compound was evaluated for kappa opioid receptor mediated agonistic effect in electrically stimulated guinea-pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetKappa-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50287927(1N-[4-cyclopropylmethyl-10,17-dihydroxy-(5R,13R,14...)
Affinity DataKi:  31nMAssay Description:Compound was evaluated for binding affinity against [3H]- bremazocine labeled kappa2 opioid receptor in guinea-pig brain homogenate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article