BDBM50288324 4-(3-Cyano-7-fluoro-5H-isothiochromeno[4,3-c]pyrazol-1-yl)-benzenesulfonamide::CHEMBL95022

SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(C#N)c2SCc3cc(F)ccc3-c12

InChI Key InChIKey=YYALXWOCHMHYLS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50288324   

LigandPNGBDBM50288324(4-(3-Cyano-7-fluoro-5H-isothiochromeno[4,3-c]pyraz...)
Affinity DataIC50: 140nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article

LigandPNGBDBM50288324(4-(3-Cyano-7-fluoro-5H-isothiochromeno[4,3-c]pyraz...)
Affinity DataIC50: 140nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM50288324(4-(3-Cyano-7-fluoro-5H-isothiochromeno[4,3-c]pyraz...)
Affinity DataIC50: 141nMAssay Description:In vitro inhibitory concentration against Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288324(4-(3-Cyano-7-fluoro-5H-isothiochromeno[4,3-c]pyraz...)
Affinity DataIC50: 760nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProstaglandin G/H synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288324(4-(3-Cyano-7-fluoro-5H-isothiochromeno[4,3-c]pyraz...)
Affinity DataIC50: 760nMAssay Description:Inhibition of COX-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article