BDBM50288325 4-(7-Methoxy-3-trifluoromethyl-5H-isothiochromeno[4,3-c]pyrazol-1-yl)-benzenesulfonamide::CHEMBL319512

SMILES COc1ccc2-c3c(SCc2c1)c(nn3-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F

InChI Key InChIKey=OFLBRQKZVMODGV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50288325   

LigandPNGBDBM50288325(4-(7-Methoxy-3-trifluoromethyl-5H-isothiochromeno[...)
Affinity DataIC50: 13nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article

LigandPNGBDBM50288325(4-(7-Methoxy-3-trifluoromethyl-5H-isothiochromeno[...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM50288325(4-(7-Methoxy-3-trifluoromethyl-5H-isothiochromeno[...)
Affinity DataIC50: 13nMAssay Description:In vitro inhibitory concentration against Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288325(4-(7-Methoxy-3-trifluoromethyl-5H-isothiochromeno[...)
Affinity DataIC50: 300nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProstaglandin G/H synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288325(4-(7-Methoxy-3-trifluoromethyl-5H-isothiochromeno[...)
Affinity DataIC50: 300nMAssay Description:Inhibition of COX-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article