BDBM50288330 4-(7-Fluoro-3-trifluoromethyl-5H-isothiochromeno[4,3-c]pyrazol-1-yl)-benzenesulfonamide::4-[11-fluoro-5-(trifluoromethyl)-7-thia-3,4-diazatricyclo[7.4.0.0^{2,6}]trideca-1(13),2(6),4,9,11-pentaen-3-yl]benzene-1-sulfonamide::CHEMBL316455

SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(c2SCc3cc(F)ccc3-c12)C(F)(F)F

InChI Key InChIKey=VRUCBLAUNYFIPA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50288330   

TargetProstaglandin G/H synthase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288330(4-(7-Fluoro-3-trifluoromethyl-5H-isothiochromeno[4...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288330(4-(7-Fluoro-3-trifluoromethyl-5H-isothiochromeno[4...)
Affinity DataIC50: 40nMAssay Description:In vitro inhibitory concentration against Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288330(4-(7-Fluoro-3-trifluoromethyl-5H-isothiochromeno[4...)
Affinity DataIC50: 40nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article

LigandPNGBDBM50288330(4-(7-Fluoro-3-trifluoromethyl-5H-isothiochromeno[4...)
Affinity DataIC50: 270nMAssay Description:Inhibition of COX-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article

LigandPNGBDBM50288330(4-(7-Fluoro-3-trifluoromethyl-5H-isothiochromeno[4...)
Affinity DataIC50: 270nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article