BDBM50291735 CHEMBL4169891

SMILES Cc1cc(F)cc(c1)[C@H](Cn1c(=O)c(N2CCN(Cc3ccc(o3)C(F)(F)F)CC2)c(C)n(Cc2c(F)cccc2F)c1=O)NCCCC(O)=O

InChI Key InChIKey=GZTDNNCBRGJPBF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50291735   

TargetGonadotropin-releasing hormone receptor(Human)
Tiumbio

Curated by ChEMBL
LigandPNGBDBM50291735(CHEMBL4169891)
Affinity DataIC50: 0.330nMAssay Description:Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cells after 1 hr by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Tiumbio

Curated by ChEMBL
LigandPNGBDBM50291735(CHEMBL4169891)
Affinity DataIC50: 4.20nMAssay Description:Displacement of [125I]D-Trp6-LHRH from monkey GnRH receptor expressed in HEK293 cells after 1 hr by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Tiumbio

Curated by ChEMBL
LigandPNGBDBM50291735(CHEMBL4169891)
Affinity DataIC50: 4.90nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells co-expressing pGL4-NFATpromoter AP-1-luc assessed as inhibition of GnRH-induced ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50291735(CHEMBL4169891)
Affinity DataIC50: 170nMAssay Description:Antagonist activity at rat GnRH receptor expressed in HEK293 cells co-expressing pGL4-NFATpromoter AP-1-luc assessed as inhibition of GnRH-induced NF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details Article
PubMed