BDBM50293720 CHEMBL541754::N-(3-(difluoromethoxy)phenyl)picolinamide::cid_44189740

SMILES FC(F)Oc1cccc(NC(=O)c2ccccn2)c1

InChI Key InChIKey=DVMQKRGCWAAYQR-UHFFFAOYSA-N

Data  4 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50293720   

TargetMetabotropic glutamate receptor 4(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293720(CHEMBL541754 | cid_44189740 | N-(3-(difluoromethox...)
Affinity DataIC50: 4.60nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293720(CHEMBL541754 | cid_44189740 | N-(3-(difluoromethox...)
Affinity DataIC50: 4.60nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293720(CHEMBL541754 | cid_44189740 | N-(3-(difluoromethox...)
Affinity DataIC50: 9.90nMAssay Description:Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293720(CHEMBL541754 | cid_44189740 | N-(3-(difluoromethox...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4 [Q124R](Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50293720(CHEMBL541754 | cid_44189740 | N-(3-(difluoromethox...)
Affinity DataEC50:  78.3nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetMetabotropic glutamate receptor 4(Rat)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293720(CHEMBL541754 | cid_44189740 | N-(3-(difluoromethox...)
Affinity DataEC50:  80nMAssay Description:Positive allosteric modulator activity at rat mGlu4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293720(CHEMBL541754 | cid_44189740 | N-(3-(difluoromethox...)
Affinity DataEC50:  80nMAssay Description:Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on thallium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293720(CHEMBL541754 | cid_44189740 | N-(3-(difluoromethox...)
Affinity DataEC50:  336nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetMetabotropic glutamate receptor 4(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293720(CHEMBL541754 | cid_44189740 | N-(3-(difluoromethox...)
Affinity DataEC50:  340nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293720(CHEMBL541754 | cid_44189740 | N-(3-(difluoromethox...)
Affinity DataEC50:  340nMAssay Description:Activity at human mGluR4 receptor expressed in CHO cells assessed as effect on calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed