BDBM50293904 1-((4-methyl-3-((2-methyl-4-(4-methyl-1H-pyrazol-5-yl)quinolin-8-yloxy)methyl)pyridin-2-yl)methyl)-3-(trifluoromethyl)pyridin-2(1H)-one::CHEMBL563956

SMILES Cc1c[nH]nc1-c1cc(C)nc2c(OCc3c(C)ccnc3Cn3cccc(c3=O)C(F)(F)F)cccc12

InChI Key InChIKey=KFVOKCIYVVCZGF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50293904   

TargetB2 bradykinin receptor(Human)
Jerini

Curated by ChEMBL
LigandPNGBDBM50293904(1-((4-methyl-3-((2-methyl-4-(4-methyl-1H-pyrazol-5...)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Jerini

Curated by ChEMBL
LigandPNGBDBM50293904(1-((4-methyl-3-((2-methyl-4-(4-methyl-1H-pyrazol-5...)
Affinity DataIC50: 8.70nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Jerini

Curated by ChEMBL
LigandPNGBDBM50293904(1-((4-methyl-3-((2-methyl-4-(4-methyl-1H-pyrazol-5...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human CYP3A4 by microtiter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Jerini

Curated by ChEMBL
LigandPNGBDBM50293904(1-((4-methyl-3-((2-methyl-4-(4-methyl-1H-pyrazol-5...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human CYP2C19 by microtiter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed