BDBM50294737 3-Benzyl-4-{3-[(1-methyl-1H-indol-7-yl)methoxy]-phenyl}-8-(trifluoromethyl)quinoline::CHEMBL551248

SMILES Cn1ccc2cccc(COc3cccc(c3)-c3c(Cc4ccccc4)cnc4c(cccc34)C(F)(F)F)c12

InChI Key InChIKey=ZBNWVQXJYIJWEI-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50294737   

TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50294737(3-Benzyl-4-{3-[(1-methyl-1H-indol-7-yl)methoxy]-ph...)
Affinity DataEC50:  2.67E+3nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50294737(3-Benzyl-4-{3-[(1-methyl-1H-indol-7-yl)methoxy]-ph...)
Affinity DataEC50:  8.44E+3nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294737(3-Benzyl-4-{3-[(1-methyl-1H-indol-7-yl)methoxy]-ph...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagged LXRbeta ligand binding domain (154-461) expressed in Escherichia c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294737(3-Benzyl-4-{3-[(1-methyl-1H-indol-7-yl)methoxy]-ph...)
Affinity DataIC50: 6.68E+5nMAssay Description:Agonist activity at human LXRalpha ligand binding domain (205-448) expressed in human HuH7 cells co-transfected with Gal4-DBD by luciferase transacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed