BDBM50296011 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid::CHEMBL558642
SMILES OC(=O)c1ccc(cc1C1CCCC1)-c1c[nH]c2ncc(cc12)-c1ccccc1
InChI Key InChIKey=WVSBGSNVCDAMCF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50296011
Affinity DataIC50: 13nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 580nMAssay Description:Inhibition of SGK1-mediated epithelial sodium channel activity in human M-1 cells assessed as short circuit current by whole cell electrophysiologica...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of SGK1 expressed in Escherichia coli or baculovirus-infected insect cells by IMAP assayMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of full-length human GST-tagged CAMKK2 using 5FAM-AKPKGNKDYHLQTCCGSLAYRRR-amide as substrate preincubated for 30 mins followed by substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human CAMKK2 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: <3nMAssay Description:Inhibition of NanoLuc-fused CAMKK2 (unknown origin) expressed in HEK293 cells after 24 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of CAMKK2 in mouse N39 cells assessed as decrease in AMPKalpha phosphorylation at T172 preincubated for 80 mins followed by inomycin addit...More data for this Ligand-Target Pair