BDBM50296700 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylbutan-1-one::CHEMBL550523

SMILES CC(CC(=O)c1ccc2OCCOc2c1)c1ccccc1

InChI Key InChIKey=JEPMPPZEWSYCGJ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50296700   

TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296700(1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylbu...)
Affinity DataIC50: 1.06E+4nMAssay Description:Allosteric antagonist activity at mGluR1 in Sprague-Dawley rat cerebellar granule cells assessed as accumulation of [3H]inositol phosphate by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296700(1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylbu...)
Affinity DataKi:  3.62E+4nMAssay Description:Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed