BDBM50296779 2-(((S)-1-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)pyrrolidin-2-yl)methylamino)nicotinonitrile::CHEMBL562072

SMILES N[C@@H](CC(=O)N1CCC[C@H]1CNc1ncccc1C#N)Cc1cc(F)c(F)cc1F

InChI Key InChIKey=HYUPCNJXAHVNMI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50296779   

TargetDipeptidyl peptidase 4(Human)
Santhera Pharmaceuticals (Switzerland)

Curated by ChEMBL
LigandPNGBDBM50296779(2-(((S)-1-((R)-3-amino-4-(2,4,5-trifluorophenyl)bu...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Santhera Pharmaceuticals (Switzerland)

Curated by ChEMBL
LigandPNGBDBM50296779(2-(((S)-1-((R)-3-amino-4-(2,4,5-trifluorophenyl)bu...)
Affinity DataIC50: 700nMAssay Description:Inhibition of DPP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Santhera Pharmaceuticals (Switzerland)

Curated by ChEMBL
LigandPNGBDBM50296779(2-(((S)-1-((R)-3-amino-4-(2,4,5-trifluorophenyl)bu...)
Affinity DataIC50: 700nMAssay Description:Inhibition of CYP2D6 in human liver microsomes by mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Santhera Pharmaceuticals (Switzerland)

Curated by ChEMBL
LigandPNGBDBM50296779(2-(((S)-1-((R)-3-amino-4-(2,4,5-trifluorophenyl)bu...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant DPP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Santhera Pharmaceuticals (Switzerland)

Curated by ChEMBL
LigandPNGBDBM50296779(2-(((S)-1-((R)-3-amino-4-(2,4,5-trifluorophenyl)bu...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human recombinant DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed