BDBM50297121 (R)-9-Methyl-1,2,8,9,10,11-hexahydro-3-oxa-6-thia-8,11-diaza-cyclohepta[b]-as-indacen-7-one::CHEMBL562754

SMILES C[C@@H]1CNc2c(sc3ccc4OCCc4c23)C(=O)N1

InChI Key InChIKey=ZLCBGFVBDKXPBZ-SSDOTTSWSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50297121   

TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297121((R)-9-Methyl-1,2,8,9,10,11-hexahydro-3-oxa-6-thia-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297121((R)-9-Methyl-1,2,8,9,10,11-hexahydro-3-oxa-6-thia-...)
Affinity DataIC50:  260nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297121((R)-9-Methyl-1,2,8,9,10,11-hexahydro-3-oxa-6-thia-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed