BDBM50297123 (R)-9-Methyl-2-phenyl-8,9,10,11-tetrahydro-3-oxa-6-thia-8,11-diaza-cyclohepta[b]-as-indacen-7-one::CHEMBL562194

SMILES C[C@@H]1CNc2c(sc3ccc4oc(cc4c23)-c2ccccc2)C(=O)N1

InChI Key InChIKey=HJSVRZBFKFCGAZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50297123   

TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297123((R)-9-Methyl-2-phenyl-8,9,10,11-tetrahydro-3-oxa-6...)
Affinity DataIC50: 150nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297123((R)-9-Methyl-2-phenyl-8,9,10,11-tetrahydro-3-oxa-6...)
Affinity DataIC50: 250nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297123((R)-9-Methyl-2-phenyl-8,9,10,11-tetrahydro-3-oxa-6...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed