BDBM50297149 (S)-7-Hydroxymethyl-3-methoxy-5,6,7,8-tetrahydro-10-thia-5,8-diaza-benzo[a]azulen-9-one::CHEMBL553397

SMILES COc1ccc2sc3c(NC[C@@H](CO)NC3=O)c2c1

InChI Key InChIKey=DXXJDEVFDVVIGG-ZETCQYMHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50297149   

TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297149((S)-7-Hydroxymethyl-3-methoxy-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  14nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297149((S)-7-Hydroxymethyl-3-methoxy-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  400nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297149((S)-7-Hydroxymethyl-3-methoxy-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  25nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed