BDBM50297366 4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphenyl-4-sulfonic Acid Ethylamide::CHEMBL569832

SMILES CCNS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1

InChI Key InChIKey=GQLPRIVQAONOIR-QGZVFWFLSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50297366   

TargetHistamine H3 receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297366(4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphen...)
Affinity DataKi:  1nMAssay Description:Inverse agonist activity against human histamine H3 receptor by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297366(4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphen...)
Affinity DataKi:  4.57nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297366(4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphen...)
Affinity DataKi:  4.57nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297366(4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphen...)
Affinity DataKi:  8nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50297366(4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphen...)
Affinity DataIC50:  3.38E+3nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed