BDBM50297681 2-butoxy-4-(4-(methylsulfonyl)phenyl)-6-(trifluoromethyl)pyrimidine::CHEMBL550126

SMILES CCCCOc1nc(cc(n1)C(F)(F)F)-c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=KBPIAEVSGWRJLE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50297681   

TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297681(2-butoxy-4-(4-(methylsulfonyl)phenyl)-6-(trifluoro...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297681(2-butoxy-4-(4-(methylsulfonyl)phenyl)-6-(trifluoro...)
Affinity DataIC50: 158nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of lipopolysaccharide-stimulated PGE2 production after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297681(2-butoxy-4-(4-(methylsulfonyl)phenyl)-6-(trifluoro...)
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of COX1 in human whole blood assessed as inhibition of lipopolysaccharide-induced TxB2 production after 30 min by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297681(2-butoxy-4-(4-(methylsulfonyl)phenyl)-6-(trifluoro...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human COX1 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed