BDBM50297691 2-tert-butoxy-4-(4-(methylsulfonyl)phenyl)-6-(trifluoromethyl)pyrimidine::CHEMBL550537

SMILES CC(C)(C)Oc1nc(cc(n1)C(F)(F)F)-c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=JMHYAXLRTPAZFX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50297691   

TargetProstaglandin G/H synthase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297691(2-tert-butoxy-4-(4-(methylsulfonyl)phenyl)-6-(trif...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297691(2-tert-butoxy-4-(4-(methylsulfonyl)phenyl)-6-(trif...)
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of human COX1 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed