BDBM50300147 (S)-4-(1-Cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile::CHEMBL573978

SMILES COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C#N)c(OC(F)F)nc2C)c1=O

InChI Key InChIKey=IJMQDYTVFNQBFD-CYBMUJFWSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50300147   

TargetCorticotropin-releasing factor receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50300147((S)-4-(1-Cyclopropyl-2-methoxyethyl)-6-[6-(difluor...)
Affinity DataIC50:  1.90nMAssay Description:Antagonist activity at CRF1 receptor in human Y79 cells assessed as inhibition of CRF-stimulated cAMP production after 30 mins by HTRF analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50300147((S)-4-(1-Cyclopropyl-2-methoxyethyl)-6-[6-(difluor...)
Affinity DataIC50:  0.860nMAssay Description:Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenate by binding titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed