BDBM50300708 8-(3-propylphenyl)-8-(4-(trifluoromethoxy)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL583887

SMILES CCCc1cccc(c1)C1(N=C(N)N2CCCN=C12)c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=UZPWRQOCXKHIDG-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50300708   

TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300708(8-(3-propylphenyl)-8-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300708(8-(3-propylphenyl)-8-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-expressing human wild type APP protein by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300708(8-(3-propylphenyl)-8-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataIC50: 9.37E+4nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed