BDBM50300713 9-(3-(2-fluoropyridin-3-yl)phenyl)-9-(4-(trifluoromethoxy)phenyl)-3,4,5,9-tetrahydro-2H-imidazo[1,5-a][1,3]diazepin-7-amine::CHEMBL565914

SMILES NC1=NC(C2=NCCCCN12)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F

InChI Key InChIKey=AMHTVOUZASNVCQ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50300713   

TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300713(9-(3-(2-fluoropyridin-3-yl)phenyl)-9-(4-(trifluoro...)
Affinity DataIC50: 80nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300713(9-(3-(2-fluoropyridin-3-yl)phenyl)-9-(4-(trifluoro...)
Affinity DataEC50:  300nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-expressing human wild type APP protein by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300713(9-(3-(2-fluoropyridin-3-yl)phenyl)-9-(4-(trifluoro...)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300713(9-(3-(2-fluoropyridin-3-yl)phenyl)-9-(4-(trifluoro...)
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed