BDBM50300717 8-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-8-(3-(2-fluoropyridin-3-yl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL566968

SMILES NC1=NC(C2=NCCCN12)(c1cccc(c1)-c1cccnc1F)c1ccc2OCCOc2c1

InChI Key InChIKey=WDVQMWDSGDTYIB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50300717   

TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300717(8-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-8-(3-(2-fl...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300717(8-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-8-(3-(2-fl...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300717(8-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-8-(3-(2-fl...)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed