BDBM50300719 (8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trifluoromethoxy)phenyl]-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL584509

SMILES NC1=N[C@@](C2=NCCCN12)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F

InChI Key InChIKey=OPSMDCTXTURNQW-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50300719   

TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300719((8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300719((8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataEC50:  300nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-expressing human wild type APP protein by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300719((8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50: 370nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300719((8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataEC50:  5.10E+3nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-expressing human wild type APP protein by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300719((8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50: 1.14E+4nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300719((8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50: 1.81E+4nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300719((8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50: 5.69E+4nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed