BDBM50300724 7-(3-(2-fluoropyridin-3-yl)phenyl)-2,2-dimethyl-7-(4-(trifluoromethoxy)phenyl)-3,7-dihydro-2H-imidazo[1,5-a]imidazol-5-amine::CHEMBL566548

SMILES CC1(C)CN2C(N)=NC(C2=N1)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F

InChI Key InChIKey=TVENQKPJIUJCEH-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50300724   

TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300724(7-(3-(2-fluoropyridin-3-yl)phenyl)-2,2-dimethyl-7-...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300724(7-(3-(2-fluoropyridin-3-yl)phenyl)-2,2-dimethyl-7-...)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-expressing human wild type APP protein by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300724(7-(3-(2-fluoropyridin-3-yl)phenyl)-2,2-dimethyl-7-...)
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300724(7-(3-(2-fluoropyridin-3-yl)phenyl)-2,2-dimethyl-7-...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed