BDBM50300731 8-phenyl-8-(3-(trifluoromethyl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine::CHEMBL565250

SMILES NC1=NC(C2=NCCCN12)(c1ccccc1)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=MVTVKWUNLOATLP-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50300731   

TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300731(8-phenyl-8-(3-(trifluoromethyl)phenyl)-2,3,4,8-tet...)
Affinity DataEC50:  5.10E+3nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-expressing human wild type APP protein by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300731(8-phenyl-8-(3-(trifluoromethyl)phenyl)-2,3,4,8-tet...)
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300731(8-phenyl-8-(3-(trifluoromethyl)phenyl)-2,3,4,8-tet...)
Affinity DataIC50: 3.01E+4nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed