BDBM50301297 2-benzyl-6,7,8,9-tetrahydro-2H-pyridazino[4,3-d]azepin-3(5H)-one::CHEMBL524778

SMILES O=c1cc2CCNCCc2nn1Cc1ccccc1

InChI Key InChIKey=ZRDIIBAKWCLJAI-UHFFFAOYSA-N

Data  2 KI  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50301297   

Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301297(2-benzyl-6,7,8,9-tetrahydro-2H-pyridazino[4,3-d]az...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-mesulergine from recombinant human 5-HT2C receptor transfected in Swiss mouse 3T3 cells after 150 mins by scintillation proximit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301297(2-benzyl-6,7,8,9-tetrahydro-2H-pyridazino[4,3-d]az...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-mesulergine from recombinant human 5-HT2C receptor transfected in Swiss mouse 3T3 cells after 150 mins by scintillation proximit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301297(2-benzyl-6,7,8,9-tetrahydro-2H-pyridazino[4,3-d]az...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301297(2-benzyl-6,7,8,9-tetrahydro-2H-pyridazino[4,3-d]az...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301297(2-benzyl-6,7,8,9-tetrahydro-2H-pyridazino[4,3-d]az...)
Affinity DataEC50:  31nMAssay Description:Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301297(2-benzyl-6,7,8,9-tetrahydro-2H-pyridazino[4,3-d]az...)
Affinity DataEC50:  358nMAssay Description:Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301297(2-benzyl-6,7,8,9-tetrahydro-2H-pyridazino[4,3-d]az...)
Affinity DataEC50:  360nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50301297(2-benzyl-6,7,8,9-tetrahydro-2H-pyridazino[4,3-d]az...)
Affinity DataEC50:  360nMAssay Description:Agonist activity at recombinant human 5-HT2B receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed