BDBM50302076 6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-isobutyl-2-methyl-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)hexanoic acid::CHEMBL570490

SMILES CC(C)C[C@H]1CC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCCC(O)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1

InChI Key InChIKey=BLVLSEPOIOLKDB-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50302076   

TargetHistone deacetylase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50302076(6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-iso...)
Affinity DataIC50: 116nMAssay Description:Inhibition of human recombinant HDAC1 after 30 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50302076(6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-iso...)
Affinity DataIC50: 120nMAssay Description:Inhibition of HDAC1 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50302076(6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-iso...)
Affinity DataIC50: 608nMAssay Description:Inhibition of human recombinant HDAC3 after 30 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50302076(6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-iso...)
Affinity DataIC50: 610nMAssay Description:Inhibition of HDAC3-NCoR2 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50302076(6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-iso...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50302076(6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-iso...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of HDAC6 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50302076(6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-iso...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of HDAC8 in human HeLa cells nuclear extract using Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50302076(6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-iso...)
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of human recombinant HDAC6 after 30 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed