BDBM50302417 2-(6-chloro-9-(3-methoxyprop-1-ynyl)-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile::CHEMBL585857

SMILES COCC#Cc1ccc2c3[nH]c(nc3c3ccc(Cl)cc3c2c1)-c1c(cccc1C#N)C#N

InChI Key InChIKey=FGSPKYRBKVYTMC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50302417   

TargetProstaglandin E synthase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50302417(2-(6-chloro-9-(3-methoxyprop-1-ynyl)-1H-phenanthro...)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]PGH2 from human recombinant PGES1 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50302417(2-(6-chloro-9-(3-methoxyprop-1-ynyl)-1H-phenanthro...)
Affinity DataIC50: 60nMAssay Description:Inhibition of mPGES1 in IL-1-beta-stimulated human A549 cells assessed as blockade of PGH2 to PGE2 conversion in presence of 50% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed